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Popular Genome Editing Tool Gets Its Close-Up
Caption: Crystal structure of the Cas9 gene-editing enzyme (light blue) in complex with an RNA guide (red) and its target DNA (yellow).Credit: Bang Wong, Broad Institute of Harvard and MIT, Cambridge,...
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Shattering News: How Chromothripsis Cured a Rare Disease
Caption: Karyotype of a woman spontaneously cured of WHIM syndrome. These chromosome pairings, which are from her white blood cells, show a normal chromosome 2 on the left, and a truncated chromosome 2...
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Manipulating Microbes: New Toolbox for Better Health?
Caption: Bacteroides thetaiotaomicron (white) living on mammalian cells in the gut (large pink cells coated in microvilli) and being activated by exogenously added compounds (small green dots) to...
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Flipping a Genetic Switch on Obesity?
When weight loss is the goal, the equation seems simple enough: consume fewer calories and burn more of them exercising. But for some people, losing and keeping off the weight is much more difficult...
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Creative Minds: Can Salamanders Show Us How to Regrow Limbs?
Jessica Whited /Credit: LightChaser Photography Jessica Whited enjoys spending time with her 6-year-old twin boys, reading them stories, and letting their imaginations roam. One thing Whited doesn’t...
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Creative Minds: Modeling Neurobiological Disorders in Stem Cells
Feng Zhang Most neurological and psychiatric disorders are profoundly complex, involving a variety of environmental and genetic factors. Researchers around the world have worked with patients and their...
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Find and Replace: DNA Editing Tool Shows Gene Therapy Promise
Caption: This image represents an infection-fighting cell called a neutrophil. In this artist’s rendering, the cell’s DNA is being “edited” to help restore its ability to fight bacterial...
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DNA-Encoded Movie Points Way to ‘Molecular Recorder’
Credit: Seth Shipman, Harvard Medical School, Boston There’s a reason why our cells store all of their genetic information as DNA. This remarkable molecule is unsurpassed for storing lots of data in an...
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